OLPC

From Wine-Wiki

Apparently it can be done.

11 April 08 wine user post read: Dear Wine users, I am attempting to run Wine inside Sugar, the OLPC GUI environment. I have managed to learn how to run wine from a nonstandard install prefix. I am now trying to generate a correctly customized .wine/ automatically. For example, I wish to set the DPI to 160 before any programs are run. I also wish to set the USERPROFILE setting to something not based on the UNIX username. How can I perform automated customization of .wine before launching anything in Wine? Where are the settings for DPI and USERPROFILE stored?

A. English: You'd have to custom compile wine and edit those settings in tools/wine.inf before compiling. [...] You could run wineprefixcreate, then use a shell script to edit ~/.wine/user.reg & ~/.wine/system.reg. Actually, correct my mistake earlier. It seems you can edit /usr/share/wine/wine.inf as well (I haven't tested this though). Try editing /usr/share/wine/wine.inf (may be different for your distribution). I just tested with a few settings, and new wine prefixes made take that as the default.